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Biochemical predictors of the treatment failure in pediatric IBD patients
Zárubová, Kristýna ; Bronský, Jiří (advisor) ; Hrdý, Jiří (referee) ; Petrášová, Miroslava (referee)
Up to 20 % of patients with IBD (inflammatory bowel disease) is diagnosed in childhood, the course of the disease tends to often be more severe and the treatment more difficult than in case of adults. Therefore, it is necessary to commence or eventually change the treatment in order to prevent development of complications. Early detection of relapse plays significant role for further course of the disease and general prognosis of the patient. Changes to laboratory parameters (e.g. to the level of fecal calprotectin) can significantly prevent the development of clinical symptoms and may indicate the necessity for control endoscopy, further escalation or change in therapy. The primary focus of this thesis are patients who underwent surgical bowel resection, who constitute one of the risk groups. Studies show that as many as 70 % of patients suffering from Crohn's disease reach the point of bowel surgery within the first 10 years of the diagnosis. According to the results, a promising predictor of relapse of the disease seems to be serum albumin, which may relate to the overall nutritional status of the organism. We have also examined the effectivity of using fecal calprotectin and CRP as relapse predictors. Testing directly in the resected bowel did not prove usability of calprotectin as a predictor,...
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Effectiveness and safety of biological therapy in inflammatory rheumatic diseases
Nekvindová, Lucie ; Závada, Jakub (advisor) ; Hendl, Jan (referee) ; Hrnčíř, Zbyněk (referee)
This thesis focuses on evaluating the effectiveness and safety of biological/targeted treatment in chronic inflammatory rheumatic diseases based on data from the ATTRA registry. The introductory chapters of the thesis give an overview of three rheumatic diseases - rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA), characterising clinical manifestation, diagnosis, therapeutical options and current treatment guidelines. The work also contains a brief summary of information about planning, creating and maintaining a clinical registry and characterises specifics related to the analysis of registry data. The practical part of the thesis was aimed at two research questions. Recently, a treat-to-target (T2T) strategy was established for RA, PsA and axSpA. Studies from daily clinical practice concerning the advantage of following T2T over usual care are still lacking. Thus, the first goal of the thesis was to evaluate whether following a treat to target strategy after not reaching low disease activity within the first six months leads to a higher chance of meeting the treatment target at the twelve-month visit. Our second goal in the thesis was to evaluate the association between therapeutic response (achieving remission and drug retention) and patients'...
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Psychosocial aspects of cancer in adults
Škardová, Kateřina ; Arnoldová, Anna (advisor) ; Ventura, Václav (referee)
Anotation: The diploma thesis " The Psychosocial Aspects of Cancer in Adults" deals with problems of the psychosocial aspects of the oncological disease and its command by adults patient.The theoretical part engages in individual phases of disease and its consequences of patient's life. It also deals with basic ethical problems which are connect with this disease. The theoretical-practical part states the basic forms and methods of supportive oncological care and it demonstrates the propsal for its classification. The practical part is elaborated by the form of interviews. The first interview was accomplished with the hospital chaplain woman and the following interviews with oncological female patiens. The main aim of the thesis is to alert to problems of the psychosocial disease aspects whose solution should be the inseparable component of the complex oncological care.
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Psychological adaptation demands to oncological diagnosis of cervival cancer: quality of life and posttraumatic growth in the phase of disease remission
Hejnová, Kateřina ; Loneková, Katarína (referee) ; Hrachovinová, Tamara (referee)
The presented thesis deals with psychological demands and specific factors of the adaptation to the oncological diagnosis "cervical cancer." The focus is on quality of life and posstraumatic growth of patients in the phase of disease remission. The theoretical part first introduces specifics of cervical cancer with consideration of patients' experience and then provides the issue of coping with the oncological disease in terms of coping and defense mechanisms. Then it elaborates the psychological adaptation to cancer disease with focus on other aspects linked to society, patients and disease altogether with problems in coping with oncological diagnosis. The theoretical part of the study is concluded with the description of demands and patients' experience in each clinical stage of the disease. The chapter of disease remis;sion is focused on theoretical background of life quality and posttraumatic growth concepts including an overview of tools for quantitative evaluation. The empirical part describes supporting psychological and other aspects, which help women to cope with cervical cancer. It also pays attention to the change of these aspects and needs with regard to clinical stage of the disease (treatment, remission and relapse) and specific demographic data (age, children, size of residence,...
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Remission of type 2 diabetes in patients on various dietary regimens
Kábelová, Adéla ; Krejčí, Hana (advisor) ; Šeda, Ondřej (referee)
Type 2 diabetes mellitus (T2D) is a highly prevalent metabolic disorder linked with the development of specific complications and comorbidities that negatively affect life quality and greatly increase the risk of an early death. The main goal of T2D treatment, which in common clinical practice comprises lifestyle changes and pharmacotherapy, is to delay onset of these complications. Evidence from many recent studies shows the ability of some interventional methods to induce remission of T2D, meaning a major improvement or complete disappearance of T2D symptoms. Besides bariatric surgery procedures, some dietary regimens such as low-energy diet, low-carbohydrate diet and intermittent fasting, can also lead to T2D remission. Attributes of these dietary regimens, especially their effect in T2D treatment, is summarized in the theoretical part of this theses. The aim of the practical part of this thesis was to assess the effect of the dietary regimens mentioned above on morphometric and biochemical parameters associated with T2D by clinical and survey research. In most of the subjects with T2D, the individual dietary regimens, more precisely low-energy diet and low-carbohydrate diet, decreased body weight, where the weight loss induced by low-carbohydrate diet was caused by major decrease in the amount...
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Needs of patients with inflammatory bowel disease.
LIDOVÁ, Michaela
This bachelor thesis focuses on the needs of patients with inflammatory bowel disease. The principal types of inflammatory bowel disease are Crohn's disease and ulcerative colitis. According to some authors, it also includes indeterminate colitis, in which the specific disease cannot be clearly identified. These two diseases are among chronic inflammatory diseases of the digestive tract. They differ in the area of the infliction of the digestive tract. Crohn's disease affects any part of the digestive tract, while ulcerative colitis affects the rectum and the large intestine. Both diseases are manifested by the frequent painful emptying of the diurnal stool with the addition of blood during an acute outburst. It is important to diagnose the disease as soon as possible and to initiate early treatment. It is also very important to follow the management of the diet and to regularly visit the doctor. In the theoretical part, we also deal with a hierarchy of needs. It is essential for a nursing team to know the patient's needs. From this knowledge, the whole nursing process may continue to develop. If a patient suffers from some of the needs, it can have a significant impact on the mental, physical and social side of the person. In the practical part of the bachelor thesis we dealt with qualitative research. The research consisted of eight respondents who suffered from one of the inflammatory bowel disease. Semi-structured interviews were conducted on the basis of a stated goal: To map the needs of patients living with inflammatory bowel disease. The research was conducted in a domestic environment. Results from data collected from patients were categorized and then processed. According to our research, it is quite clear that the most important thing for these patients is to satisfy the need for emptying. This thesis will help students to get new information about the diseases in question and could also serve as a source of information for patients with newly diagnosed inflammatory bowel disease.
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Case Study of Physiotherapy Treatment of a Patient with the Diagnosis of multiple sclerosis
Nosková, Kateřina ; Neuwirthová, Svatava (advisor) ; Vobořilová, Lenka (referee)
Name: Case study of physiotherapy treatment of a patient with the diagnosis of multiple sclerosis Summary: Bachelor thesis deals with the topic of multiple sclerosis, when the main aim of this work is to precisely introduce and reveal the run of this disease. The theoretical part consists of the definition of the disease, specifics of etiology, symptoms, run and possible treatments. Single treatment methods are aimed on patient's perception of his/her body or single stimulations with his/her own senses. The inseparable part of the therapy is the mental condition of the patient. The practical part considers case report of patient L. S. involving incoming assessment, description of chosen single therapies, out coming assessment, evaluation of the treatment at the end of the therapy and conclusion. The undividable part of the work is the proposal of long and short-term plan of therapy. Key words: multiple sclerosis, physiotherapy, rehabilitation, relapse, remission, paresis, myelin
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Psychological adaptation demands to oncological diagnosis of cervival cancer: quality of life and posttraumatic growth in the phase of disease remission
Hejnová, Kateřina ; Loneková, Katarína (referee) ; Hrachovinová, Tamara (referee)
The presented thesis deals with psychological demands and specific factors of the adaptation to the oncological diagnosis "cervical cancer." The focus is on quality of life and posstraumatic growth of patients in the phase of disease remission. The theoretical part first introduces specifics of cervical cancer with consideration of patients' experience and then provides the issue of coping with the oncological disease in terms of coping and defense mechanisms. Then it elaborates the psychological adaptation to cancer disease with focus on other aspects linked to society, patients and disease altogether with problems in coping with oncological diagnosis. The theoretical part of the study is concluded with the description of demands and patients' experience in each clinical stage of the disease. The chapter of disease remis;sion is focused on theoretical background of life quality and posttraumatic growth concepts including an overview of tools for quantitative evaluation. The empirical part describes supporting psychological and other aspects, which help women to cope with cervical cancer. It also pays attention to the change of these aspects and needs with regard to clinical stage of the disease (treatment, remission and relapse) and specific demographic data (age, children, size of residence,...
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Psychosocial aspects of cancer in adults
Škardová, Kateřina ; Arnoldová, Anna (advisor) ; Ventura, Václav (referee)
Anotation: The diploma thesis " The Psychosocial Aspects of Cancer in Adults" deals with problems of the psychosocial aspects of the oncological disease and its command by adults patient.The theoretical part engages in individual phases of disease and its consequences of patient's life. It also deals with basic ethical problems which are connect with this disease. The theoretical-practical part states the basic forms and methods of supportive oncological care and it demonstrates the propsal for its classification. The practical part is elaborated by the form of interviews. The first interview was accomplished with the hospital chaplain woman and the following interviews with oncological female patiens. The main aim of the thesis is to alert to problems of the psychosocial disease aspects whose solution should be the inseparable component of the complex oncological care.
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